It is considered critically endangered due to its tiny range (it inhabits an area of less than 10 km2), continuing habitat loss, and the illegal capture of salamanders for the wild animal trade. In 2008, the wild population was estimated at less than 1,000 individuals. However, a new survey in 2014 estimates a population of over 9,000 adults, and range estimate that could provide habitat for more than 40,000 Neurergus kaiseri.

The Luristan newt is a candidate for CITES listing. It also has a captive breeding program involving several European and North American zoos, such as Sedgwick County Zoo. Iran is planning on starting its own breeding program.